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Issue 3, 2013
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Magnetic Fe3O4graphene composites as targeted drug nanocarriers for pH-activated release

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Abstract

A novel nanocarrier of magnetic Fe3O4graphene nanocomposites (MGNs) was proposed as an effective drug delivery system for cancer treatment. The nanocarrier was synthesized by covalently attaching modified Fe3O4 nanoparticles onto water-soluble graphene sheets via the formation of an amide bond with the aid of 1-ethyl-3-(3-dimethyaminopropyl) carbodiimide. The obtained MGNs exhibited excellent dispersibility and stability in aqueous solution and they also exhibited superparamagnetic properties with a saturation magnetization of 23.096 emu g−1. An efficient loading of 5-fluorouracil (5-FU) on MGNs as high as 0.35 mg mg−1 was obtained. Furthermore, the in vitro drug release of 5-FU was examined in pH 6.9 and pH 4.0 buffers at 37 °C, and showed strong pH dependence. Transmission electron microscope observations revealed that MGNs can be internalized efficiently by HepG2 cells. More importantly, the cytotoxicity evaluation shows that the resulting MGNs exhibit excellent biocompatibility. The as-prepared nanocarrier system combined the advantages of the superparamagnetic iron oxide nanoparticles and water-soluble graphene sheets, which will find many potential applications in biomedicine and biomaterials.

Graphical abstract: Magnetic Fe3O4–graphene composites as targeted drug nanocarriers for pH-activated release

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Publication details

The article was received on 29 Jun 2012, accepted on 05 Dec 2012 and first published on 07 Dec 2012


Article type: Paper
DOI: 10.1039/C2NR33158F
Nanoscale, 2013,5, 1143-1152

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    Magnetic Fe3O4graphene composites as targeted drug nanocarriers for pH-activated release

    X. Fan, G. Jiao, W. Zhao, P. Jin and X. Li, Nanoscale, 2013, 5, 1143
    DOI: 10.1039/C2NR33158F

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