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Issue 8, 2013
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Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

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Abstract

Covering: up to 2013

The heterologous expression of microbial natural product biosynthetic pathways coupled with advanced DNA engineering enables optimisation of product yields, functional elucidation of cryptic gene clusters, and generation of novel derivatives. This review summarises the recent advances in cloning and maintenance of natural product biosynthetic gene clusters for heterologous expression and the efforts fundamental for discovering novel natural products in the post-genomics era, with a focus on polyketide synthases (PKSs) and non-ribosomal polypeptide synthetases (NRPS).

Graphical abstract: Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

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Publication details

The article was received on 17 Apr 2013 and first published on 05 Jul 2013


Article type: Review Article
DOI: 10.1039/C3NP70034H
Nat. Prod. Rep., 2013,30, 1121-1138

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    Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

    S. E. Ongley, X. Bian, B. A. Neilan and R. Müller, Nat. Prod. Rep., 2013, 30, 1121
    DOI: 10.1039/C3NP70034H

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