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Issue 7, 2013
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Drug specific, tuning of an ionic liquid's hydrophilic–lipophilic balance to improve water solubility of poorly soluble active pharmaceutical ingredients

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Abstract

Amphotericin B and itraconazole were used to demonstrate that ionic liquids can be designed or chosen to provide tunable hydrophilicity in one ion and lipophilicity in the other allowing one to match the structural requirements needed to solubilize poorly water soluble active pharmaceutical ingredients. These liquid, amphiphilic excipients could be used as both drug delivery systems and solubilization agents to improve the aqueous solubility of many drugs. The solubility in deionized water, simulated gastric fluid, simulated intestinal fluid, and phosphate buffer solution was greatly improved over current methods for drug delivery by utilizing designed ionic liquids as excipients.

Graphical abstract: Drug specific, tuning of an ionic liquid's hydrophilic–lipophilic balance to improve water solubility of poorly soluble active pharmaceutical ingredients

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Publication details

The article was received on 30 Apr 2013, accepted on 06 May 2013 and first published on 07 May 2013


Article type: Paper
DOI: 10.1039/C3NJ00454F
New J. Chem., 2013,37, 2196-2202

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    Drug specific, tuning of an ionic liquid's hydrophilic–lipophilic balance to improve water solubility of poorly soluble active pharmaceutical ingredients

    P. D. McCrary, P. A. Beasley, G. Gurau, A. Narita, P. S. Barber, O. A. Cojocaru and R. D. Rogers, New J. Chem., 2013, 37, 2196
    DOI: 10.1039/C3NJ00454F

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