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Issue 7, 2013
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Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

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Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

Graphical abstract: Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

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Article information


Submitted
04 Mar 2013
Accepted
17 May 2013
First published
20 May 2013

Med. Chem. Commun., 2013,4, 1105-1108
Article type
Concise Article

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

J. A. Parkinson, F. J. Scott, C. J. Suckling and G. Wilson, Med. Chem. Commun., 2013, 4, 1105
DOI: 10.1039/C3MD00071K

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