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Issue 6, 2013
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Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

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Abstract

We have described the synthesis of β-amino alcohol based β-lactam–isatin chimeras along with their in vitro evaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of β-lactam and C-5 of isatin with preference for a chloro-substituent for good activity.

Graphical abstract: Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

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Supplementary files

Article information


Submitted
19 Feb 2013
Accepted
09 Apr 2013
First published
16 Apr 2013

Med. Chem. Commun., 2013,4, 1018-1024
Article type
Concise Article

Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

Nisha, V. Mehra, M. Hopper, N. Patel, D. Hall, L. A. Wrischnik, K. M. Land and V. Kumar, Med. Chem. Commun., 2013, 4, 1018
DOI: 10.1039/C3MD00057E

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