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Issue 2, 2013
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Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

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Abstract

The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum.

Graphical abstract: Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

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Publication details

The article was received on 02 May 2012, accepted on 19 Oct 2012 and first published on 22 Oct 2012


Article type: Concise Article
DOI: 10.1039/C2MD20112G
Med. Chem. Commun., 2013,4, 310-316

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    Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

    J. Im, S. Kim, Y. Jeong, W. Kim, D. Lee, W. S. Lee, Y. Chang, K. Kim and S. Chung, Med. Chem. Commun., 2013, 4, 310
    DOI: 10.1039/C2MD20112G

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