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Issue 3, 2013
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Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

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Abstract

Neutral, non- or not easily-ionizable active pharmaceutical ingredients can take advantage of the unique property sets of ionic liquids by functionalization with hydrolyzable, charged (or ionizable) groups in the preparation of ionic liquid prodrugs as demonstrated here with the synthesis, characterization, and hydrolysis of cationic acetaminophen prodrugs paired with the docusate anion.

Graphical abstract: Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

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Publication details

The article was received on 03 Dec 2012, accepted on 14 Jan 2013 and first published on 17 Jan 2013


Article type: Concise Article
DOI: 10.1039/C3MD20359J
Med. Chem. Commun., 2013,4, 559-563

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    Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

    O. A. Cojocaru, K. Bica, G. Gurau, A. Narita, P. D. McCrary, J. L. Shamshina, P. S. Barber and R. D. Rogers, Med. Chem. Commun., 2013, 4, 559
    DOI: 10.1039/C3MD20359J

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