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Issue 4, 2013
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Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis

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Abstract

The potent antimycobacterial activity of (±)-platencin is reported. Complete inhibition of Mycobacterium smegmatis growth was observed at MICs of 0.5 μg mL−1 and 0.3 μg mL−1 under aerobic and hypoxic conditions, respectively. Notably, the compound exhibited potent bacteriostatic activities towards Mycobacterium tuberculosis H37Rv (MIC = 2 μg mL−1), multi-drug-resistant M. tuberculosis (MIC = 1 μg mL−1), and extensively drug-resistant M. tuberculosis (MIC = 1 μg mL−1). An overexpression study of the transformants of M. smegmatis revealed that platencin selectively targeted Mt-KasB and modestly inhibited Mt-KasA and Mt-FabH.

Graphical abstract: Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis

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Publication details

The article was received on 12 Jan 2013, accepted on 31 Jan 2013 and first published on 01 Mar 2013


Article type: Concise Article
DOI: 10.1039/C3MD00016H
Med. Chem. Commun., 2013,4, 720-723

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    Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis

    G. A. I. Moustafa, S. Nojima, Y. Yamano, A. Aono, M. Arai, S. Mitarai, T. Tanaka and T. Yoshimitsu, Med. Chem. Commun., 2013, 4, 720
    DOI: 10.1039/C3MD00016H

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