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Issue 4, 2013
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Searching for a needle in a stack of needles: challenges in metaproteomics data analysis

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Abstract

In the past years the integral study of microbial communities of varying complexity has gained increasing research interest. Mass spectrometry-driven metaproteomics enables the analysis of such communities on the functional level, but this fledgling field still faces various technical and semantic challenges regarding experimental data analysis and interpretation. In the present review, we outline the hurdles involved and attempt to cover the most valuable methods and software implementations available to researchers in the field today. Beyond merely focusing on protein identification, we provide an overview on different data pre- and post-processing steps, such as metabolic pathway analysis, that can be useful in a typical metaproteomics workflow. Finally, we briefly discuss directions for future work.

Graphical abstract: Searching for a needle in a stack of needles: challenges in metaproteomics data analysis

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Article information


Submitted
05 Oct 2012
Accepted
03 Dec 2012
First published
03 Dec 2012

Mol. BioSyst., 2013,9, 578-585
Article type
Review Article

Searching for a needle in a stack of needles: challenges in metaproteomics data analysis

T. Muth, D. Benndorf, U. Reichl, E. Rapp and L. Martens, Mol. BioSyst., 2013, 9, 578
DOI: 10.1039/C2MB25415H

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