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Issue 12, 2013
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Lab-on-a-chip technologies for single-molecule studies

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Recent developments on various lab-on-a-chip techniques allow miniaturized and integrated devices to perform on-chip single-molecule studies. Fluidic-based platforms that utilize unique microscale fluidic behavior are capable of conducting single-molecule experiments with high sensitivities and throughputs, while biomolecular systems can be studied on-chip using techniques such as DNA curtains, magnetic tweezers, and solid-state nanopores. The advances of these on-chip single-molecule techniques lead to next-generation lab-on-a-chip devices, such as DNA transistors, and single-molecule real-time (SMRT) technology for rapid and low-cost whole genome DNA sequencing. In this Focus article, we will discuss some recent successes in the development of lab-on-a-chip techniques for single-molecule studies and expound our thoughts on the near future of on-chip single-molecule studies.

Graphical abstract: Lab-on-a-chip technologies for single-molecule studies

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Publication details

The article was first published on 14 May 2013

Article type: Focus
DOI: 10.1039/C3LC90042H
Lab Chip, 2013,13, 2183-2198

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    Lab-on-a-chip technologies for single-molecule studies

    Y. Zhao, D. Chen, H. Yue, J. B. French, J. Rufo, S. J. Benkovic and T. J. Huang, Lab Chip, 2013, 13, 2183
    DOI: 10.1039/C3LC90042H

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