Jump to main content
Jump to site search

Issue 18, 2013
Previous Article Next Article

Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

Author affiliations

Abstract

The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs. Tremendous efforts are placed into development of novel regenerative strategies, involving (stem) cells, soluble factors, biomaterials or combinations thereof, as a result of the growing need caused by continuous population aging. To satisfy this need, fast and reliable assessment of (biological) performance is sought, not only to select the potentially interesting candidates, but also to rule out poor ones at an early stage of development. Microfluidics may provide a new avenue to accelerate research and development in the field of regenerative medicine as it has proven its maturity for the realization of high-throughput screening platforms. In addition, microfluidic systems offer other advantages such as the possibility to create in vivo-like microenvironments. Besides the complexity of organs or tissues that need to be regenerated, regenerative medicine brings additional challenges of complex regeneration processes and strategies. The question therefore arises whether so much complexity can be integrated into microfluidic systems without compromising reliability and throughput of assays. With this review, we aim to investigate whether microfluidics can become widely applied in regenerative medicine research and/or strategies.

Graphical abstract: Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

Back to tab navigation

Publication details

The article was received on 01 Mar 2013, accepted on 31 May 2013 and first published on 31 May 2013


Article type: Critical Review
DOI: 10.1039/C3LC50293G
Lab Chip, 2013,13, 3512-3528
  • Open access: Creative Commons BY license
  •   Request permissions

    Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

    B. Harink, S. Le Gac, R. Truckenmüller, C. van Blitterswijk and P. Habibovic, Lab Chip, 2013, 13, 3512
    DOI: 10.1039/C3LC50293G

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements