Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

Valentina Arima; Giancarlo Pascali; Oliver Lade; Hans R. Kretschmer; Ingo Bernsdorf; Victoria Hammond; Paul Watts; Francesco De Leonardis; Mark D. Tarn; Nicole Pamme; Benjamin Z. Cvetkovic; Petra S. Dittrich; Nikola Vasovic; Russell Duane; Aleksandar Jaksic; Antonella Zacheo; Alessandra Zizzari; Lucia Marra; Elisabetta Perrone; Piero A. Salvadori; Rosaria Rinaldi

doi:10.1039/C3LC00055A

Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals†

Valentina Arima,*^a Giancarlo Pascali,^bc Oliver Lade,^d Hans R. Kretschmer,^d Ingo Bernsdorf,^d Victoria Hammond,^e Paul Watts,^ef Francesco De Leonardis,^e Mark D. Tarn,^e Nicole Pamme,^e Benjamin Z. Cvetkovic,^g Petra S. Dittrich,^g Nikola Vasovic,^h Russell Duane,^h Aleksandar Jaksic,^h Antonella Zacheo,^ai Alessandra Zizzari,^a Lucia Marra,^a Elisabetta Perrone,^a Piero A. Salvadori^b and Rosaria Rinaldi^ai

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* Corresponding authors

^a National Nanotechnology Laboratory (NNL)-Institute of Nanoscience (NANO), CNR, Via per Arnesano 16, 73100 Lecce, Italy
E-mail: valentina.arima@nano.cnr.it
Fax: +39 0832 298230
Tel: +39 0832 298218

^b Institute of Clinical Physiology, CNR, Via Moruzzi 1, 56124 Pisa, Italy

^c Australian Nuclear Sciences and Technology Organization, Life Sciences Division, Locked Bag 2001, Kirrawee DC, NSW 2232, Australia

^d Siemens AG, Siemensdamm 50, 13629 Berlin, Germany

^e Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK

^f InnoVenton: NMMU Institute for Chemical Technology, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031, RSA

^g Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Str. 10, CH-8093 Zurich, Switzerland

^h Tyndall National Institute, Lee Maltings, Dyke Parade, Cork, Ireland

ⁱ Università del Salento, Dipartimento di Matematica e Fisica “E. De Giorgi”, ex Collegio Fiorini Campus extraurbano, via per Arnesano, 73100 Lecce, Italy

Abstract

We have developed an integrated microfluidic platform for producing 2-[¹⁸F]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.

Lab on a Chip

Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals†

Abstract

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Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

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