Jump to main content
Jump to site search

Issue 24, 2013
Previous Article Next Article

Ultrasensitive protein detection: a case for microfluidic magnetic bead-based assays

Author affiliations

Abstract

We review the use of magnetic micro- and nanoparticles (‘magnetic beads’) in microfluidic systems for ultrasensitive protein detection. During recent years magnetic beads have been used frequently in immunoassays, either as mobile substrates on which the target antigen is captured, as detection labels, or simultaneously as substrates and labels. The major part of the reviewed work has as application the detection of antibodies or disease biomarkers in serum or of biotoxins from food samples. Several of the most sensitive assays allow protein detection down to fg mL−1 concentrations. We benchmark the performance of these microfluidic magnetic bead-based assays with the most promising earlier work and with alternative solutions.

Graphical abstract: Ultrasensitive protein detection: a case for microfluidic magnetic bead-based assays

Back to tab navigation

Article information


Submitted
16 Apr 2013
Accepted
03 Sep 2013
First published
03 Sep 2013

Lab Chip, 2013,13, 4711-4739
Article type
Critical Review

Ultrasensitive protein detection: a case for microfluidic magnetic bead-based assays

H. C. Tekin and M. A. M. Gijs, Lab Chip, 2013, 13, 4711
DOI: 10.1039/C3LC50477H

Social activity

Search articles by author

Spotlight

Advertisements