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Issue 16, 2013
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Assessment of pathogenic bacteria using periodic actuation

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Abstract

A new analytical platform for the assessment of pathogenic bacteria is presented. It is based on a robust technology which is able to amplify the signal to noise ratio providing fast and sensitive detection of target pathogenic bacteria. The system uses a custom made AC electrical impedance analyser to measure, using a lab on a chip platform, the oscillations of magnetically labelled analytes when applying a periodic magnetic field. The concentration of pathogenic Escherichia coli O157:H7 chosen as bacterial model was determined based on the amplitude of the electrical impedance oscillations at a selected AC frequency. The analytical platform provides a limit of detection of 102 cells ml−1, has a fast analysis time, and is amenable for the detection of other target cells. The system has simple design suitable for portability and automated operation.

Graphical abstract: Assessment of pathogenic bacteria using periodic actuation

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Publication details

The article was received on 02 Apr 2013, accepted on 28 May 2013 and first published on 29 May 2013


Article type: Paper
DOI: 10.1039/C3LC50411E
Lab Chip, 2013,13, 3192-3198

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    Assessment of pathogenic bacteria using periodic actuation

    S. David, C. Polonschii, M. Gheorghiu, D. Bratu, A. Dobre and E. Gheorghiu, Lab Chip, 2013, 13, 3192
    DOI: 10.1039/C3LC50411E

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