Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks

Irep Gözen; Mehrnaz Shaali; Alar Ainla; Bahanur Örtmen; Inga Põldsalu; Kiryl Kustanovich; Gavin D. M. Jeffries; Zoran Konkoli; Paul Dommersnes; Aldo Jesorka

doi:10.1039/C3LC50391G

Thermal migration of molecular lipid films as a contactless fabrication strategy for lipidnanotube networks†‡

Irep Gözen,^a Mehrnaz Shaali,^a Alar Ainla,^a Bahanur Örtmen,^a Inga Põldsalu,^b Kiryl Kustanovich,^a Gavin D. M. Jeffries,^a Zoran Konkoli,^a Paul Dommersnes^c and Aldo Jesorka*^a

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^a Chalmers University of Technology, Göteborg, SE-412 96, Sweden
E-mail: aldo@chalmers.se

^b IMS Lab, University of Tartu, Nooruse 1, 50411 Tartu, Estonia

^c Centre for Advanced Study, Norwegian Academy of Science and Letters, Oslo, Norway

Abstract

We demonstrate the contactless generation of lipid nanotube networks by means of thermally induced migration of flat giant unilamellar vesicles (FGUVs), covering micro-scale areas on oxidized aluminum surfaces. A temperature gradient with a reach of 20 μm was generated using a focused IR laser, leading to a surface adhesion gradient, along which FGUVs could be relocated. We report on suitable lipid–substrate combinations, highlighting the critical importance of the electrostatic interactions between the engineered substrate and the membrane for reversible migration of intact vesicles.

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Thermal migration of molecular lipid films as a contactless fabrication strategy for lipidnanotube networks†‡

Abstract

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Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks

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