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Issue 14, 2013
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Molecular-level dengue fever diagnostic devices made out of paper

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Abstract

This paper describes the development of nucleic acid detection in paper using a combination of commercial fluorescent probes and DNA ladders, and provides us with a better understanding of the interactions between double-stranded DNA (the amplified products in this study), fiber structures in paper, and fluorescent probes. The amplified products (the reverse-transcription and amplification of dengue virus serotype-2 RNA via RT-LAMP) in this study were subsequently fluorescently labeled in paper-based test zones (on our paper-based diagnostic device), thus fluorescent probes were used to perform the diagnosis of dengue fever, specific to serotype-2.

Graphical abstract: Molecular-level dengue fever diagnostic devices made out of paper

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Article information


Submitted
30 Jan 2013
Accepted
12 Mar 2013
First published
12 Mar 2013

Lab Chip, 2013,13, 2686-2692
Article type
Paper

Molecular-level dengue fever diagnostic devices made out of paper

S. Lo, S. Yang, D. Yao, J. Chen, W. Tu and C. Cheng, Lab Chip, 2013, 13, 2686
DOI: 10.1039/C3LC50135C

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