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Issue 12, 2013
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Microfluidic platforms for mechanobiology

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Abstract

Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on in vivo experiments with limited control or direct access, or on large-scale in vitro studies lacking many of the potentially important physiological factors. With the advent of microfluidics, many of the previous limitations of in vitro testing were eliminated or reduced through greater control or combined functionalities. At the same time, imaging capabilities were tremendously enhanced. In this review, we discuss how microfluidics has transformed the study of mechanotransduction. This is done in the context of the various cell types that exhibit force-induced responses and the new biological insights that have been elucidated. We also discuss new microfluidic studies that could produce even more realistic models of in vivo conditions by combining multiple stimuli or creating a more realistic microenvironment.

Graphical abstract: Microfluidic platforms for mechanobiology

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Publication details

The article was received on 19 Dec 2012, accepted on 03 Apr 2013 and first published on 04 Apr 2013


Article type: Critical Review
DOI: 10.1039/C3LC41393D
Lab Chip, 2013,13, 2252-2267
  • Open access: Creative Commons BY license
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    Microfluidic platforms for mechanobiology

    W. J. Polacheck, R. Li, S. G. M. Uzel and R. D. Kamm, Lab Chip, 2013, 13, 2252
    DOI: 10.1039/C3LC41393D

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