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Issue 4, 2013
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Integrating zebrafish toxicology and nanoscience for safer product development

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Abstract

The design, manufacture and application of safer products and manufacturing processes have been important goals over the last decade and will advance in the future under the umbrella of “Green Chemistry”. In this review, we focus on the burgeoning diversity of new engineered nanomaterials (ENMs) and the prescient need for a nanotoxicology paradigm that quickly identifies potentially hazardous nanochemistries. Advances in predictive toxicological modeling in the developing zebrafish offer the most immediate translation to human hazard that is practically achievable with high throughput approaches. Translation in a vertebrate model that is also a low cost alternative to rodents for hazard prediction has been a desirable but elusive testing paradigm. The utility of zebrafish, if applied early in the ENM discovery pipeline, could greatly enhance efforts toward greener and more efficient nanoscience. Early pipeline detection of human and environmental health impacts will quickly inform decisions in the design and production of safer commercial ENMs.

Graphical abstract: Integrating zebrafish toxicology and nanoscience for safer product development

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Article information


Submitted
14 Nov 2012
Accepted
16 Jan 2013
First published
17 Jan 2013

Green Chem., 2013,15, 872-880
Article type
Critical Review

Integrating zebrafish toxicology and nanoscience for safer product development

K. Kim and R. L. Tanguay, Green Chem., 2013, 15, 872
DOI: 10.1039/C3GC36806H

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