Jump to main content
Jump to site search

Issue 5, 2013

Efficient three-component coupling catalysed by mesoporous copper–aluminum based nanocomposites

Author affiliations

Abstract

Traditional synthesis methods for propargylamines have several drawbacks. A recently developed alternative route is the so-called “A3 coupling” in which an alkyne, an aldehyde, and an amine are coupled together. Typically, these reactions are catalysed by homogeneous gold salts, organogold complexes or silver salts. But these homogeneous catalysts are expensive and their separation is difficult. Here we report the discovery that solid Cu/Al/oxide mesoporous “sponges” are excellent A3 coupling catalysts. These materials are robust, inexpensive, and easy to make. They give good to excellent yields (87–97%) for a wide range of substrates. Being heterogeneous, these catalysts are also easy to handle and separate from the reaction mixture, and can be recycled with no loss of activity.

Graphical abstract: Efficient three-component coupling catalysed by mesoporous copper–aluminum based nanocomposites

Supplementary files

Article information


Submitted
16 Aug 2012
Accepted
30 Jan 2013
First published
31 Jan 2013

This article is Open Access

Green Chem., 2013,15, 1238-1243
Article type
Paper

Efficient three-component coupling catalysed by mesoporous copper–aluminum based nanocomposites

J. Dulle, K. Thirunavukkarasu, M. C. Mittelmeijer-Hazeleger, D. V. Andreeva, N. R. Shiju and G. Rothenberg, Green Chem., 2013, 15, 1238 DOI: 10.1039/C3GC36607C

This is an Open Access article. The full version of this article can be posted on a website/blog, posted on an intranet, photocopied, emailed, distributed in a course pack or distributed in Continuing Medical Education (CME) materials provided that it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements