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Issue 8, 2013
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Metal- and solvent-free synthesis of N-sulfonylformamidines

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Abstract

A solvent-free green synthesis of N-sulfonylformamidines is reported via the direct condensation of N,N-dimethylformamide dimethyl acetal (DMF-DMA) and sulfonamide derivatives at room temperature. The described method avoids the use of metal catalysts as well as hazardous solvents, which are not permitted for pharmaceutical manufacture, for the reactions or isolation of products. Hence, the current work presents a fast and efficient alternative to earlier reported methods. The mild nature of the procedure is demonstrated by varied functional group tolerance.

Graphical abstract: Metal- and solvent-free synthesis of N-sulfonylformamidines

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Publication details

The article was received on 28 Apr 2013, accepted on 12 Jun 2013 and first published on 13 Jun 2013


Article type: Paper
DOI: 10.1039/C3GC40797G
Green Chem., 2013,15, 2294-2301

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    Metal- and solvent-free synthesis of N-sulfonylformamidines

    N. Chandna, N. Chandak, P. Kumar, J. K. Kapoor and P. K. Sharma, Green Chem., 2013, 15, 2294
    DOI: 10.1039/C3GC40797G

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