Issue 3, 2013
From the journal:

Green Chemistry

Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide†

Donna S. MacMillan,a   Jane Murray,b   Helen F. Sneddon,c   Craig Jamiesona  and  Allan J. B. Watson*a  

* Corresponding authors

a Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, UK
E-mail: allan.watson.100@strath.ac.uk
Fax: +44 (0) 141 548 4822
Tel: +44 (0) 141 548 2439

b Sigma-Aldrich, The Old Brickyard, New Road, Gillingham, Dorset, UK

c Green Chemistry Performance Unit, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK

Abstract

A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamide.

Graphical abstract: Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide

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Article information

DOI
https://doi.org/10.1039/C2GC36900A
Article type
Communication
Submitted
27 Nov 2012
Accepted
19 Dec 2012
First published
19 Dec 2012
This article is Open Access
Creative Commons BY license

Green Chem., 2013,15, 596-600

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Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide

D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Green Chem., 2013, 15, 596 DOI: 10.1039/C2GC36900A

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