Issue 14, 2013
From the journal:

Dalton Transactions

A novel polynuclear Cu(i)–sulfur cluster with 1,2-dithiolate-o-carborane ligands as a potential in vitro antitumour agent and its DNA binding properties†

Zhong Han,a   Jin Jiang,a   Jing Lu,a   Dacheng Li,a   Shuang Cheng*b  and  Jianmin Dou*a  

* Corresponding authors

a Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, P. R. China
E-mail: dougroup@163.com
Fax: (+86)635-8239001
Tel: (+86)635-8239298

b School of Agriculture, Liaocheng University, Liaocheng, P. R. China
E-mail: chengshuang@lcu.edu.cn

Abstract

A novel polynuclear Cu(I)–sulfur cluster, 1 (C54H62B30Cu6N8S6), bearing 1,2-dithiolate-o-carborane and 1,10-phenanthroline ligands was synthesized. The complex displayed rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells and efficient CT-DNA binding.

Graphical abstract: A novel polynuclear Cu(i)–sulfur cluster with 1,2-dithiolate-o-carborane ligands as a potential in vitro antitumour agent and its DNA binding properties

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Article information

DOI
https://doi.org/10.1039/C3DT33076A
Article type
Communication
Submitted
22 Dec 2012
Accepted
06 Feb 2013
First published
07 Feb 2013

Dalton Trans., 2013,42, 4777-4780

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A novel polynuclear Cu(I)–sulfur cluster with 1,2-dithiolate-o-carborane ligands as a potential in vitro antitumour agent and its DNA binding properties

Z. Han, J. Jiang, J. Lu, D. Li, S. Cheng and J. Dou, Dalton Trans., 2013, 42, 4777 DOI: 10.1039/C3DT33076A

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