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Issue 24, 2013
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Recent advances in enzymatic and chemical deracemisation of racemic compounds

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Abstract

Deracemisation of racemic compounds is still the most important strategy to produce optically pure compounds despite many recent advances in asymmetric synthesis. Especially deracemisation approaches that give rise to single enantiomers are preferred, which can be achieved either by invoking organocatalysts, metal complexes or enzymes – leading to dynamic kinetic resolution – or by applying other deracemisation techniques based on stereoinversion or enantioconvergence. In this tutorial review, we will provide an overview of new, recently developed approaches that lead to the important goal of creating organic compounds of single chirality.

Graphical abstract: Recent advances in enzymatic and chemical deracemisation of racemic compounds

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Publication details

The article was received on 30 May 2013 and first published on 24 Sep 2013


Article type: Tutorial Review
DOI: 10.1039/C3CS60175G
Chem. Soc. Rev., 2013,42, 9268-9282
  • Open access: Creative Commons BY license
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    Recent advances in enzymatic and chemical deracemisation of racemic compounds

    M. Rachwalski, N. Vermue and F. P. J. T. Rutjes, Chem. Soc. Rev., 2013, 42, 9268
    DOI: 10.1039/C3CS60175G

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