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Issue 20, 2013
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Selective sensing of saccharides using simple boronic acids and their aggregates

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Abstract

The reversible boronic aciddiol interaction empowers boronic acid receptors' saccharide binding capacities, rendering them a class of lectin mimetic, termed “boronlectins”. Boronic acids follow lectin functions not just in being able to bind saccharides, but in multivalent saccharide binding that enhances both affinity and selectivity. For almost a decade, efforts have been made to achieve and improve selectivity for given saccharide targets, most notably glucose, by using properly positioned boronic acids, offering multivalent interactions. Incorporation of several boronic acid groups into a covalent framework or non-covalent assembly of boronic acid are two general methods used to create such smart sensors, of which the latter resembles lectin oligomerisation that affords multivalent saccharide-binding architectures. In this review, we discuss supramolecular selective sensing of saccharides by using simple boronic acids in their aggregate forms, after a brief survey of the general aspects of boronic acid-based saccharide sensing.

Graphical abstract: Selective sensing of saccharides using simple boronic acids and their aggregates

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Article information


Submitted
29 Apr 2013
First published
16 Jul 2013

This article is Open Access

Chem. Soc. Rev., 2013,42, 8032-8048
Article type
Review Article

Selective sensing of saccharides using simple boronic acids and their aggregates

X. Wu, Z. Li, X. Chen, J. S. Fossey, T. D. James and Y. Jiang, Chem. Soc. Rev., 2013, 42, 8032
DOI: 10.1039/C3CS60148J

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