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Issue 16, 2013
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Conjugated polymernanoparticles: preparation, properties, functionalization and biological applications

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Abstract

In the past few years, conjugated polymer nanoparticles (CPNs) have been successfully prepared and applied in the biological field because of their unique opto-electronic properties. The rapid development of CPNs is mainly attributed to their simple synthesis procedures and easy separation steps. The advantages of CPNs include high brightness, excellent photostability, low cytotoxicity, high quantum yield and versatile surface modification. The functionalization of CPNs with specific recognition elements imparts them good ability for targeted recognition and imaging in vitro and in vivo. CPNs can be applied to deliver drug and gene, and simultaneously to real-time monitor the release process due to their self-luminous characteristics. Moreover, CPNs can sensitize oxygen molecules to generate reactive oxygen species (ROS) which can kill adjacent bacteria and tumor cells. In this tutorial review, we provide a recent development of the preparation methods, properties, and functionalization strategies of CPNs, especially discussing their biological applications in targeted imaging, drug/gene delivery and biomedicine. The challenges and outlooks in this field will also be discussed.

Graphical abstract: Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications

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Article information


Submitted
30 Jan 2013
First published
07 Jun 2013

Chem. Soc. Rev., 2013,42, 6620-6633
Article type
Tutorial Review

Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications

L. Feng, C. Zhu, H. Yuan, L. Liu, F. Lv and S. Wang, Chem. Soc. Rev., 2013, 42, 6620 DOI: 10.1039/C3CS60036J

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