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Issue 11, 2013
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Multivalent glycoliposomes and micelles to study carbohydrate–protein and carbohydrate–carbohydrate interactions

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Abstract

This tutorial review describes multivalent carbohydrate–protein and carbohydrate–carbohydrate interaction studies that utilize self-assembled aggregates of thermodynamically stable liposomes and micelles. Strategies to prepare multivalent glycoliposomes and micelles include: (i) insertion of synthetic glycolipids into matrix lipids; (ii) preparation of glycolipids that aggregate to liposomes and micelles and (iii) modification of the hydrophilic surfaces with desired sugars. Several design strategies have been developed in order to obtain constituent glycolipids, having multivalent sugar moieties and their subsequent interactions with proteins were assessed in relation to the type of linkers that connect the hydrophilic and lipophilic segments. Lipophilic segments other than alkyl chains have also been developed. Polymer based glycoliposomes and micelles form an emphasis. Further, glycoliposomes facilitate studies of carbohydrate–carbohydrate interactions. An overview of the various types of glycoliposomes and micelles used to study carbohydrate–protein and carbohydrate–carbohydrate recognition phenomena is presented.

Graphical abstract: Multivalent glycoliposomes and micelles to study carbohydrate–protein and carbohydrate–carbohydrate interactions

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Publication details

The article was received on 02 Jan 2013 and first published on 13 Mar 2013


Article type: Tutorial Review
DOI: 10.1039/C3CS00001J
Chem. Soc. Rev., 2013,42, 4640-4656

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    Multivalent glycoliposomes and micelles to study carbohydrate–protein and carbohydrate–carbohydrate interactions

    N. Jayaraman, K. Maiti and K. Naresh, Chem. Soc. Rev., 2013, 42, 4640
    DOI: 10.1039/C3CS00001J

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