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Issue 10, 2013
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Carbohydrate microarrays

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Abstract

In the last decade, carbohydrate microarrays have been core technologies for analyzing carbohydrate-mediated recognition events in a high-throughput fashion. A number of methods have been exploited for immobilizing glycans on the solid surface in a microarray format. This microarray-based technology has been widely employed for rapid analysis of the glycan binding properties of lectins and antibodies, the quantitative measurements of glycan–protein interactions, detection of cells and pathogens, identification of disease-related anti-glycan antibodies for diagnosis, and fast assessment of substrate specificities of glycosyltransferases. This review covers the construction of carbohydrate microarrays, detection methods of carbohydrate microarrays and their applications in biological and biomedical research.

Graphical abstract: Carbohydrate microarrays

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Publication details

The article was received on 29 Sep 2012 and first published on 28 Nov 2012


Article type: Review Article
DOI: 10.1039/C2CS35401B
Chem. Soc. Rev., 2013,42, 4310-4326

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    Carbohydrate microarrays

    S. Park, J. C. Gildersleeve, O. Blixt and I. Shin, Chem. Soc. Rev., 2013, 42, 4310
    DOI: 10.1039/C2CS35401B

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