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Issue 2, 2013
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Homogeneous palladium-catalyzed asymmetric hydrogenation

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The transition metal catalyzed asymmetric hydrogenation of unsaturated compounds arguably presents one of the most attractive methods for the synthesis of chiral compounds. Over the last few decades, Pd has gradually grown up as a new and popular metal catalyst in homogeneous asymmetric hydrogenation the same as traditional Ru, Rh and Ir catalysts. Much progress has been successfully achieved in the asymmetric reduction of imines, enamines, olefins, ketones and heteroarenes. It was also found that palladium catalyzed asymmetric hydrogenation could be used as a key step in tandem reactions to quickly synthesize chiral compounds. This tutorial review intends to offer an overview of recent progress in homogeneous palladium catalyzed asymmetric hydrogenation and should serve as an inspiration for further advances in this area.

Graphical abstract: Homogeneous palladium-catalyzed asymmetric hydrogenation

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Publication details

The article was received on 13 Aug 2012 and first published on 09 Nov 2012

Article type: Tutorial Review
DOI: 10.1039/C2CS35333D
Chem. Soc. Rev., 2013,42, 497-511

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    Homogeneous palladium-catalyzed asymmetric hydrogenation

    Q. Chen, Z. Ye, Y. Duan and Y. Zhou, Chem. Soc. Rev., 2013, 42, 497
    DOI: 10.1039/C2CS35333D

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