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Issue 1, 2013
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BODIPY dyes in photodynamic therapy

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Abstract

BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with 3O2. In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

Graphical abstract: BODIPY dyes in photodynamic therapy

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Publication details

The article was received on 15 Jun 2012 and first published on 26 Sep 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35216H
Chem. Soc. Rev., 2013,42, 77-88

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    BODIPY dyes in photodynamic therapy

    A. Kamkaew, S. H. Lim, H. B. Lee, L. V. Kiew, L. Y. Chung and K. Burgess, Chem. Soc. Rev., 2013, 42, 77
    DOI: 10.1039/C2CS35216H

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