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Issue 42, 2013
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The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging

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Abstract

Six free base tetrapyrrolic chromophores, three quinoline-annulated porphyrins and three morpholinobacteriochlorins, that absorb light in the near-IR range and possess, in comparison to regular porphyrins, unusually low fluorescence emission and 1O2 quantum yields were tested with respect to their efficacy as novel molecular photo-acoustic imaging contrast agents in a tissue phantom, providing an up to ∼2.5-fold contrast enhancement over that of the benchmark contrast agent ICG. The testing protocol compares the photoacoustic signal output strength upon absorption of approximately the same light energy. Some relationships between photophysical parameters of the dyes and the resulting photoacoustic signal strength could be derived.

Graphical abstract: The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging

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Publication details

The article was received on 24 May 2013, accepted on 04 Sep 2013 and first published on 05 Sep 2013


Article type: Paper
DOI: 10.1039/C3CP52193A
Phys. Chem. Chem. Phys., 2013,15, 18502-18509

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    The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging

    A. Abuteen, S. Zanganeh, J. Akhigbe, L. P. Samankumara, A. Aguirre, N. Biswal, M. Braune, A. Vollertsen, B. Röder, C. Brückner and Q. Zhu, Phys. Chem. Chem. Phys., 2013, 15, 18502
    DOI: 10.1039/C3CP52193A

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