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Issue 37, 2013
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Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins

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Abstract

The contribution of Tyr–His vs. Cys–His interacting pairs to the scaffold stability of DPro–LPro nucleated peptide β-hairpins has been examined. We present direct evidence for the superiority of the Cys–His pairs, mediated by sulphur–imidazole interactions, as added stabilizing agents of the β-hairpin scaffold.

Graphical abstract: Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins

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Publication details

The article was received on 04 Jul 2013, accepted on 26 Jul 2013 and first published on 29 Jul 2013


Article type: Communication
DOI: 10.1039/C3CP52770K
Phys. Chem. Chem. Phys., 2013,15, 15321-15324

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    Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins

    K. M. Makwana, S. Raghothama and R. Mahalakshmi, Phys. Chem. Chem. Phys., 2013, 15, 15321
    DOI: 10.1039/C3CP52770K

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