Issue 38, 2013
From the journal:

Physical Chemistry Chemical Physics

Metal-enhanced fluorescence in the life sciences: here, now and beyond

Wei Deng,a   Fang Xie,b   Henrique T. M. C. M. Baltarac  and  Ewa M. Goldys*ac  

* Corresponding authors

a MQ BioFocus Research Centre, Macquarie University, North Ryde, Sydney, Australia
E-mail: ewa.goldys@mq.edu.au
Fax: +61-2-9850-8115
Tel: +61-2-9850-8902

b Department of Materials, Imperial College London, Exhibition Road, London, England, UK

c MQ Photonics Research Centre, Macquarie University, North Ryde, Sydney, Australia

Abstract

We discuss the phenomenon of enhanced fluorescence in the proximity of metal nanostructures addressing the question of how much fluorescence signal can be obtained from fluorophores in such altered environments. We review its applicability for the methodologies used in the life science, such as immunoassays, flow cytometry and bioimaging. Experimental and theoretical scenarios employing various metal nanostructures – such as homogeneous enhancing substrates, fluorescence-enhancing microbeads, and metal core–dielectric shell nanocomposites – are described.

Graphical abstract: Metal-enhanced fluorescence in the life sciences: here, now and beyond

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Article information

DOI
https://doi.org/10.1039/C3CP50206F
Article type
Perspective
Submitted
17 Jan 2013
Accepted
22 Mar 2013
First published
22 Mar 2013

Phys. Chem. Chem. Phys., 2013,15, 15695-15708

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Metal-enhanced fluorescence in the life sciences: here, now and beyond

W. Deng, F. Xie, H. T. M. C. M. Baltar and E. M. Goldys, Phys. Chem. Chem. Phys., 2013, 15, 15695 DOI: 10.1039/C3CP50206F

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