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Issue 95, 2013
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Trifluoromethyl ketones: properties, preparation, and application

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Abstract

Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.

Graphical abstract: Trifluoromethyl ketones: properties, preparation, and application

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Article information


Submitted
15 Aug 2013
Accepted
11 Oct 2013
First published
14 Oct 2013

Chem. Commun., 2013,49, 11133-11148
Article type
Feature Article

Trifluoromethyl ketones: properties, preparation, and application

C. B. Kelly, M. A. Mercadante and N. E. Leadbeater, Chem. Commun., 2013, 49, 11133
DOI: 10.1039/C3CC46266H

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