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Issue 84, 2013
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Intramolecular arylation of amino acid enolates

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Abstract

Dianionic enolates formed from N′-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N′-aryl ring, leading to a hydantoin derivative of a quaternary amino acid. In situ IR studies allow identification of four intermediates on the reaction pathway.

Graphical abstract: Intramolecular arylation of amino acid enolates

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Article information


Submitted
13 Aug 2013
Accepted
04 Sep 2013
First published
05 Sep 2013

Chem. Commun., 2013,49, 9734-9736
Article type
Communication

Intramolecular arylation of amino acid enolates

R. C. Atkinson, D. J. Leonard, J. Maury, D. Castagnolo, N. Volz and J. Clayden, Chem. Commun., 2013, 49, 9734
DOI: 10.1039/C3CC46193A

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