Issue 98, 2013
From the journal:

Chemical Communications

Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria†

Kyuha Chong,a   Taeyun Ku,b   Phei Er Saw,c   Sangyong Jon,c   Ji-Ho Park*b  and  Chulhee Choi*ab  

* Corresponding authors

a Graduate School of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea

b Department of Bio and Brain Engineering, KAIST, Republic of Korea
E-mail: jihopark@kaist.ac.kr, cchoi@kaist.ac.kr
Fax: +82-42-350-4380
Tel: +82-42-350-4361

c Department of Biological Science, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea

Abstract

We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.

Graphical abstract: Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC46166A
Article type
Communication
Submitted
12 Aug 2013
Accepted
11 Sep 2013
First published
11 Sep 2013

Chem. Commun., 2013,49, 11476-11478

Permissions

Request permissions

Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

K. Chong, T. Ku, P. E. Saw, S. Jon, J. Park and C. Choi, Chem. Commun., 2013, 49, 11476 DOI: 10.1039/C3CC46166A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements