Issue 92, 2013

Oxidative 1,2-difunctionalization of activated alkenes with benzylic C(sp3)–H bonds and aryl C(sp2)–H bonds

Abstract

DTBP (di-tert-butyl peroxide) is utilized to mediate oxidative 1,2-difunctionalization of activated alkenes with an aryl C(sp2)–H bond and a benzylic C(sp3)–H bond for the synthesis of functionalized oxindoles. This reaction is a new organomediated strategy for alkene difunctionalization facilitated by Lewis acids.

Graphical abstract: Oxidative 1,2-difunctionalization of activated alkenes with benzylic C(sp3)–H bonds and aryl C(sp2)–H bonds

Supplementary files

Article information

Article type
Communication
Submitted
31 Jul 2013
Accepted
30 Aug 2013
First published
30 Aug 2013

Chem. Commun., 2013,49, 10817-10819

Oxidative 1,2-difunctionalization of activated alkenes with benzylic C(sp3)–H bonds and aryl C(sp2)–H bonds

M. Zhou, C. Wang, R. Song, Y. Liu, W. Wei and J. Li, Chem. Commun., 2013, 49, 10817 DOI: 10.1039/C3CC45861J

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