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Issue 86, 2013
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A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis

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Abstract

We designed a novel strategy for sensitively detecting the activity of α-2,8-polysialyltransferase (PST) by a combination of ganglioside GD3 functionalized gold nanoparticles and inactive endosialidase. We anticipate that this new method will facilitate the search for PST inhibitors as well as for improved mutant forms of PST in directed evolution experiments.

Graphical abstract: A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis

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Publication details

The article was received on 09 Jul 2013, accepted on 03 Sep 2013 and first published on 09 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC45147J
Chem. Commun., 2013,49, 10166-10168

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    A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis

    C. Yu, L. Huang, D. H. Kwan, W. W. Wakarchuk, S. G. Withers and C. Lin, Chem. Commun., 2013, 49, 10166
    DOI: 10.1039/C3CC45147J

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