CoCEST: cobalt(ii) amide-appended paraCEST MRI contrast agents†
Abstract
The first examples of air-stable CoII paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.