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Issue 76, 2013
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Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

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Abstract

The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.

Graphical abstract: Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

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Supplementary files

Article information


Submitted
24 Jun 2013
Accepted
30 Jul 2013
First published
31 Jul 2013

This article is Open Access

Chem. Commun., 2013,49, 8453-8455
Article type
Communication

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

P. Murat, M. V. Gormally, D. Sanders, M. D. Antonio and S. Balasubramanian, Chem. Commun., 2013, 49, 8453
DOI: 10.1039/C3CC44737E

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