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Issue 50, 2013
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Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

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Abstract

A mild and efficient copper-catalyzed trifluoromethylation reaction which involves the cyclization of oximes has been developed. This method provides a convenient access to a variety of useful CF3-containing 4,5-dihydroisoxazoles by constructing a C–CF3 bond and a C–O bond in one step.

Graphical abstract: Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

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Publication details

The article was received on 09 Apr 2013, accepted on 03 May 2013 and first published on 03 May 2013


Article type: Communication
DOI: 10.1039/C3CC42588F
Chem. Commun., 2013,49, 5687-5689

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    Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

    Y. He, L. Li, Y. Yang, Y. Wang, J. Luo, X. Liu and Y. Liang, Chem. Commun., 2013, 49, 5687
    DOI: 10.1039/C3CC42588F

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