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Issue 60, 2013
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Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

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Abstract

A solid-phase synthesis approach to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) specific for trypsin is described. The protein is immobilized on a solid support upon which thermoresponsive MIP-NPs are synthesized. The MIP-NPs are released by a simple temperature change, resulting in synthetic antibody mimics exhibiting high specificity and selectivity for trypsin.

Graphical abstract: Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

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Article information


Submitted
06 Mar 2013
Accepted
03 Jun 2013
First published
04 Jun 2013

Chem. Commun., 2013,49, 6746-6748
Article type
Communication

Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

S. Ambrosini, S. Beyazit, K. Haupt and B. Tse Sum Bui, Chem. Commun., 2013, 49, 6746
DOI: 10.1039/C3CC41701H

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