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Issue 42, 2013
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A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers

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Abstract

We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum – using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.

Graphical abstract: A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers

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Supplementary files

Article information


Submitted
17 Feb 2013
Accepted
11 Apr 2013
First published
18 Apr 2013

Chem. Commun., 2013,49, 4830-4832
Article type
Communication

A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers

S. M. Bromfield, P. Posocco, M. Fermeglia, S. Pricl, J. Rodríguez-López and D. K. Smith, Chem. Commun., 2013, 49, 4830
DOI: 10.1039/C3CC41251B

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