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Issue 24, 2013
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Light uncages a copper complex to induce nonapoptotic cell death

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Abstract

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Graphical abstract: Light uncages a copper complex to induce nonapoptotic cell death

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Supplementary files

Article information


Submitted
13 Dec 2012
Accepted
04 Feb 2013
First published
15 Feb 2013

Chem. Commun., 2013,49, 2460-2462
Article type
Communication

Light uncages a copper complex to induce nonapoptotic cell death

A. A. Kumbhar, A. T. Franks, R. J. Butcher and K. J. Franz, Chem. Commun., 2013, 49, 2460
DOI: 10.1039/C3CC38927H

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