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Issue 19, 2013
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The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action

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Abstract

The first structure determination of a neuraminidase inhibitor, oseltamivir phosphate, the active component of the anti-influenza agent Tamiflu, was achieved by single crystal X-ray diffraction with synchrotron radiation. The structure reproduces to a great extent the binding of the inhibitor in the neuraminidase active site and provides more accurate structural parameters as well as detailed insight into the binding preferences of the inhibitor.

Graphical abstract: The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action

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Article information


Submitted
07 Dec 2012
Accepted
18 Jan 2013
First published
21 Jan 2013

Chem. Commun., 2013,49, 1948-1950
Article type
Communication

The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action

P. Naumov, N. Yasuda, W. M. Rabeh and J. Bernstein, Chem. Commun., 2013, 49, 1948
DOI: 10.1039/C3CC38801H

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