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Issue 91, 2013
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One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction

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Abstract

A facile and efficient one-pot, single-step method for deracemizing a broad range of 2-hydroxyacids to (R)-2-hydroxyacids was established by combination of resting cells of an (S)-hydroxyacid dehydrogenase-producing microorganism and an (R)-ketoacid reductase-producing microorganism.

Graphical abstract: One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction

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Publication details

The article was received on 15 Aug 2013, accepted on 23 Sep 2013 and first published on 24 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC46240D
Chem. Commun., 2013,49, 10706-10708

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    One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction

    Y. Xue, Y. Zheng, Y. Zhang, J. Sun, Z. Liu and Y. Shen, Chem. Commun., 2013, 49, 10706
    DOI: 10.1039/C3CC46240D

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