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Issue 85, 2013
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Synthetic modification of salinomycin: selective O-acylation and biological evaluation

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Abstract

Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose–response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.

Graphical abstract: Synthetic modification of salinomycin: selective O-acylation and biological evaluation

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Publication details

The article was received on 05 Aug 2013, accepted on 21 Aug 2013 and first published on 03 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC45983G
Chem. Commun., 2013,49, 9944-9946
  • Open access: Creative Commons BY license
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    Synthetic modification of salinomycin: selective O-acylation and biological evaluation

    B. Borgström, X. Huang, M. Pošta, C. Hegardt, S. Oredsson and D. Strand, Chem. Commun., 2013, 49, 9944
    DOI: 10.1039/C3CC45983G

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