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Issue 85, 2013
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Synthetic modification of salinomycin: selective O-acylation and biological evaluation

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Abstract

Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose–response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.

Graphical abstract: Synthetic modification of salinomycin: selective O-acylation and biological evaluation

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Supplementary files

Article information


Submitted
05 Aug 2013
Accepted
21 Aug 2013
First published
03 Sep 2013

This article is Open Access

Chem. Commun., 2013,49, 9944-9946
Article type
Communication

Synthetic modification of salinomycin: selective O-acylation and biological evaluation

B. Borgström, X. Huang, M. Pošta, C. Hegardt, S. Oredsson and D. Strand, Chem. Commun., 2013, 49, 9944
DOI: 10.1039/C3CC45983G

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