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Issue 96, 2013
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Enantioselective Friedel–Crafts alkylation for synthesis of 2-substituted indole derivatives

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Abstract

An efficient catalytic asymmetric intermolecular C2 Friedel–Crafts alkylation reaction between N-methyl skatole and β,γ-unsaturated α-ketoesters has been realized by a chiral N,N′-dioxide-Ni(II) complex. The corresponding indole derivatives were obtained in good yield (up to 96%) with excellent enantioselectivities (up to 99% ee) under mild reaction conditions.

Graphical abstract: Enantioselective Friedel–Crafts alkylation for synthesis of 2-substituted indole derivatives

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Supplementary files

Article information


Submitted
25 Jul 2013
Accepted
07 Oct 2013
First published
25 Oct 2013

Chem. Commun., 2013,49, 11311-11313
Article type
Communication

Enantioselective Friedel–Crafts alkylation for synthesis of 2-substituted indole derivatives

Y. Zhang, X. Liu, X. Zhao, J. Zhang, L. Zhou, L. Lin and X. Feng, Chem. Commun., 2013, 49, 11311
DOI: 10.1039/C3CC45665J

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