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Issue 93, 2013
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Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

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Abstract

The corrole-based catalytic antioxidant 1-Fe reduced the cholesterol biosynthesis ability of macrophages, harvested from mice treated with it. 1-Fe and a non-redox active analogue of it affect the committed step of the biosynthetic pathway – the HMG-CoA reductase catalysed reaction – by acting as allosteric inhibitors of this key enzyme.

Graphical abstract: Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

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Publication details

The article was received on 24 Jun 2013, accepted on 25 Jul 2013 and first published on 26 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC44740E
Chem. Commun., 2013,49, 10917-10919

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    Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

    A. Haber, A. Abu-Younis Ali, M. Aviram and Z. Gross, Chem. Commun., 2013, 49, 10917
    DOI: 10.1039/C3CC44740E

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