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Issue 74, 2013
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Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

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Abstract

A parallel, versatile and efficient route to synthesis of pyrrolidinoindoline and tetrahydrofuranoindoline alkaloids from cinnamyl derivatives has been developed, featuring a domino Rh-catalyzed hydroformylation–double cyclization sequence. This method can be applied to the syntheses of anti-Alzheimer drugs such as physostigmine and physovenine.

Graphical abstract: Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

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The article was received on 02 May 2013, accepted on 15 Jul 2013 and first published on 17 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC43257B
Chem. Commun., 2013,49, 8232-8234

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    Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

    W. Chiou, C. Kao, J. Tsai and Y. Chang, Chem. Commun., 2013, 49, 8232
    DOI: 10.1039/C3CC43257B

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