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Issue 74, 2013
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Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

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Abstract

A parallel, versatile and efficient route to synthesis of pyrrolidinoindoline and tetrahydrofuranoindoline alkaloids from cinnamyl derivatives has been developed, featuring a domino Rh-catalyzed hydroformylation–double cyclization sequence. This method can be applied to the syntheses of anti-Alzheimer drugs such as physostigmine and physovenine.

Graphical abstract: Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

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Submitted
02 May 2013
Accepted
15 Jul 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 8232-8234
Article type
Communication

Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

W. Chiou, C. Kao, J. Tsai and Y. Chang, Chem. Commun., 2013, 49, 8232
DOI: 10.1039/C3CC43257B

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