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Issue 58, 2013
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Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

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Abstract

A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl γ-aminobutyronitriles and δ-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.

Graphical abstract: Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

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Article information


Submitted
18 Apr 2013
Accepted
30 May 2013
First published
30 May 2013

Chem. Commun., 2013,49, 6558-6560
Article type
Communication

Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

D. Stephens, Y. Zhang, M. Cormier, G. Chavez, H. Arman and O. V. Larionov, Chem. Commun., 2013, 49, 6558
DOI: 10.1039/C3CC42854K

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